A Safe is a secure box or room that is used to store valuables or confidential documents. A person who breaks into a safe is usually called a safecracker. Some equipment used to break into safes include a Safe Cracker and a Code Breaker.
When Cate Archer plied her trade as a Thief during her days as "The Fox", she utilized a safe cracker to break into several safes in a local Brasserie (aka a pub) to gain access to the money located within.
In 1967, a UNITY agent infiltrated the French Embassy located in Santiago, Chile. A wall safe was located just behind the consuls desk. The agent had opened the safe and was rummaging through a Filing Cabinet just before Dmitrij Volkov caught and strangled him.
Baron Archibald Dumas was very proud of the safe located in the Dumas Towers in England. It contained the "paperwork" needed to run Dumas Industrial Enterprises and was protected by a deadly security system that included Infrared Beams and Poison Gas.
The H.A.R.M. Indian Headquarters had a multi-trapped safe in which they kept information on Project: Omega. As the safe was too well guarded, Archer had to "apply" for a job with H.A.R.M. by infiltrating a nearby Evil Alliance office and returning with the contents of their safe.